Speckle targeted PIP5K1A-regulated poly(A) polymerase (TUT1)
Homo sapiens — UniProt Q9H6E5
Data last refreshed: (UniProt release unknown)
Key facts
Speckle targeted PIP5K1A-regulated poly(A) polymerase (TUT1) is a protein from Homo sapiens identified by UniProt accession Q9H6E5, 874 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9H6E5; gene symbol TUT1.
- Organism: Homo sapiens.
- Length: 874 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Abnormal brain morphology and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Speckle targeted PIP5K1A-regulated poly(A) polymerase |
|---|---|
| UniProt accession | Q9H6E5 |
| Gene | TUT1 |
| Organism | Homo sapiens |
| Length | 874 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Abnormal brain morphology · score 0.27
- FEV/FVC ratio · score 0.10
- BMI-adjusted waist-hip ratio · score 0.08
- forced expiratory volume · score 0.07
- triglyceride measurement · score 0.06
- physical activity measurement · score 0.06
- vital capacity · score 0.05
- BMI-adjusted hip circumference · score 0.05
- high density lipoprotein cholesterol measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6E5-F1 | alphafold | PREDICTED | 74.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6E5.
Amino-acid sequence (874 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TUT1?
The strongest Open Targets associations for TUT1 are neurodegenerative disease, Abnormal brain morphology, FEV/FVC ratio, BMI-adjusted waist-hip ratio and forced expiratory volume.
How long is the TUT1 protein?
The Homo sapiens TUT1 protein (UniProt Q9H6E5) is 874 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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