Trimeric intracellular cation channel type A (TMEM38A)
Homo sapiens — UniProt Q9H6F2
Data last refreshed: (UniProt release unknown)
Key facts
Trimeric intracellular cation channel type A (TMEM38A) is a protein from Homo sapiens identified by UniProt accession Q9H6F2, 299 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9H6F2; gene symbol TMEM38A.
- Organism: Homo sapiens.
- Length: 299 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): neutrophil-to-lymphocyte ratio, calf circumference measurement and medulloblastoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Trimeric intracellular cation channel type A |
|---|---|
| UniProt accession | Q9H6F2 |
| Gene | TMEM38A |
| Organism | Homo sapiens |
| Length | 299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- neutrophil-to-lymphocyte ratio · score 0.22
- calf circumference measurement · score 0.02
- medulloblastoma · score 0.02
- Emery-Dreifuss muscular dystrophy · score 0.01
- astrocytoma · score 0.01
- primitive neuroectodermal tumor · score 0.01
- facioscapulohumeral muscular dystrophy · score 0.01
- chronic myelogenous leukemia · score 0.01
- Facioscapulohumeral dystrophy · score 0.01
- glioblastoma multiforme · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6F2-F1 | alphafold | PREDICTED | 80.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6F2.
Amino-acid sequence (299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM38A?
The strongest Open Targets associations for TMEM38A are neutrophil-to-lymphocyte ratio, calf circumference measurement, medulloblastoma, Emery-Dreifuss muscular dystrophy and astrocytoma.
How long is the TMEM38A protein?
The Homo sapiens TMEM38A protein (UniProt Q9H6F2) is 299 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6F2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6F2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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