Receptor expression-enhancing protein 4 (REEP4)
Homo sapiens — UniProt Q9H6H4
Data last refreshed: (UniProt release unknown)
Key facts
Receptor expression-enhancing protein 4 (REEP4) is a protein from Homo sapiens identified by UniProt accession Q9H6H4, 257 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9H6H4; gene symbol REEP4.
- Organism: Homo sapiens.
- Length: 257 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, prostate adenocarcinoma and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Receptor expression-enhancing protein 4 |
|---|---|
| UniProt accession | Q9H6H4 |
| Gene | REEP4 |
| Organism | Homo sapiens |
| Length | 257 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- prostate adenocarcinoma · score 0.18
- acute myeloid leukemia · score 0.15
- neoplasm · score 0.04
- glioblastoma multiforme · score 0.02
- cancer · score 0.02
- Crohn's disease · score 0.01
- clear cell renal carcinoma · score 0.01
- benign essential blepharospasm · score 0.01
- Blepharospasm - oromandibular dystonia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6H4-F1 | alphafold | PREDICTED | 64.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6H4.
Amino-acid sequence (257 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with REEP4?
The strongest Open Targets associations for REEP4 are neurodegenerative disease, prostate adenocarcinoma, acute myeloid leukemia, neoplasm and glioblastoma multiforme.
How long is the REEP4 protein?
The Homo sapiens REEP4 protein (UniProt Q9H6H4) is 257 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6H4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6H4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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