Transcription factor SOX-17 (SOX17)
Homo sapiens — UniProt Q9H6I2
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor SOX-17 (SOX17) is a protein from Homo sapiens identified by UniProt accession Q9H6I2, 414 residues long. MolForge cross-references it against 0 known binders and 326 disease associations.
- UniProt accession: Q9H6I2; gene symbol SOX17.
- Organism: Homo sapiens.
- Length: 414 amino acids.
- Top disease associations (Open Targets): familial vesicoureteral reflux, pulmonary arterial hypertension and heritable pulmonary arterial hypertension.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor SOX-17 |
|---|---|
| UniProt accession | Q9H6I2 |
| Gene | SOX17 |
| Organism | Homo sapiens |
| Length | 414 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (326)
Diseases linked to this target (Open Targets).
- familial vesicoureteral reflux · score 0.55
- pulmonary arterial hypertension · score 0.50
- heritable pulmonary arterial hypertension · score 0.47
- vesicoureteral reflux · score 0.46
- endometrial cancer · score 0.42
- hematocrit · score 0.30
- red blood cell density measurement · score 0.28
- brain aneurysm · score 0.27
- viral load · score 0.26
- platelet component distribution width · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6I2-F1 | alphafold | PREDICTED | 57.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6I2.
Amino-acid sequence (414 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOX17?
The strongest Open Targets associations for SOX17 are familial vesicoureteral reflux, pulmonary arterial hypertension, heritable pulmonary arterial hypertension, vesicoureteral reflux and endometrial cancer.
How long is the SOX17 protein?
The Homo sapiens SOX17 protein (UniProt Q9H6I2) is 414 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6I2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6I2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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