Optic atrophy 3 protein (OPA3)
Homo sapiens — UniProt Q9H6K4
Data last refreshed: (UniProt release unknown)
Key facts
Optic atrophy 3 protein (OPA3) is a protein from Homo sapiens identified by UniProt accession Q9H6K4, 179 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q9H6K4; gene symbol OPA3.
- Organism: Homo sapiens.
- Length: 179 amino acids.
- Top disease associations (Open Targets): 3-methylglutaconic aciduria type 3, optic atrophy 3 and Autosomal dominant optic atrophy and cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Optic atrophy 3 protein |
|---|---|
| UniProt accession | Q9H6K4 |
| Gene | OPA3 |
| Organism | Homo sapiens |
| Length | 179 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- 3-methylglutaconic aciduria type 3 · score 0.81
- optic atrophy 3 · score 0.79
- Autosomal dominant optic atrophy and cataract · score 0.79
- neurodegenerative disease · score 0.52
- autosomal dominant optic atrophy · score 0.42
- achromatopsia · score 0.27
- C-reactive protein measurement · score 0.19
- genetic disorder · score 0.18
- Hypoplasia of the fovea · score 0.11
- foveal hypoplasia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6K4-F1 | alphafold | PREDICTED | 82.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6K4.
Amino-acid sequence (179 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OPA3?
The strongest Open Targets associations for OPA3 are 3-methylglutaconic aciduria type 3, optic atrophy 3, Autosomal dominant optic atrophy and cataract, neurodegenerative disease and autosomal dominant optic atrophy.
How long is the OPA3 protein?
The Homo sapiens OPA3 protein (UniProt Q9H6K4) is 179 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6K4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6K4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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