Transmembrane protein 231 (TMEM231)
Homo sapiens — UniProt Q9H6L2
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 231 (TMEM231) is a protein from Homo sapiens identified by UniProt accession Q9H6L2, 316 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q9H6L2; gene symbol TMEM231.
- Organism: Homo sapiens.
- Length: 316 amino acids.
- Top disease associations (Open Targets): Joubert syndrome with ocular defect, Meckel syndrome and Joubert syndrome with oculorenal defect.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 231 |
|---|---|
| UniProt accession | Q9H6L2 |
| Gene | TMEM231 |
| Organism | Homo sapiens |
| Length | 316 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- Joubert syndrome with ocular defect · score 0.75
- Meckel syndrome · score 0.73
- Joubert syndrome with oculorenal defect · score 0.62
- Joubert syndrome and related disorders · score 0.52
- ciliopathy · score 0.49
- orofaciodigital syndrome type 6 · score 0.37
- Orofaciodigital syndrome type 3 · score 0.34
- genetic disorder · score 0.34
- congenital hydronephrosis · score 0.26
- congenital anomaly of kidney and urinary tract · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6L2-F1 | alphafold | PREDICTED | 88.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6L2.
Amino-acid sequence (316 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM231?
The strongest Open Targets associations for TMEM231 are Joubert syndrome with ocular defect, Meckel syndrome, Joubert syndrome with oculorenal defect, Joubert syndrome and related disorders and ciliopathy.
How long is the TMEM231 protein?
The Homo sapiens TMEM231 protein (UniProt Q9H6L2) is 316 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6L2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6L2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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