Reticulophagy regulator 1 (RETREG1)
Homo sapiens — UniProt Q9H6L5
Data last refreshed: (UniProt release unknown)
Key facts
Reticulophagy regulator 1 (RETREG1) is a protein from Homo sapiens identified by UniProt accession Q9H6L5, 497 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.
- UniProt accession: Q9H6L5; gene symbol RETREG1.
- Organism: Homo sapiens.
- Length: 497 amino acids.
- Top disease associations (Open Targets): hereditary sensory and autonomic neuropathy, hereditary sensory and autonomic neuropathy type 2 and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Reticulophagy regulator 1 |
|---|---|
| UniProt accession | Q9H6L5 |
| Gene | RETREG1 |
| Organism | Homo sapiens |
| Length | 497 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (119)
Diseases linked to this target (Open Targets).
- hereditary sensory and autonomic neuropathy · score 0.68
- hereditary sensory and autonomic neuropathy type 2 · score 0.64
- genetic disorder · score 0.49
- lymphocyte count · score 0.39
- reticulocyte count · score 0.36
- insulin sensitivity measurement · score 0.31
- body mass index · score 0.31
- reticulocyte measurement · score 0.29
- neuritic plaque measurement · score 0.26
- PHF-tau measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6L5-F1 | alphafold | PREDICTED | 59.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6L5.
Amino-acid sequence (497 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RETREG1?
The strongest Open Targets associations for RETREG1 are hereditary sensory and autonomic neuropathy, hereditary sensory and autonomic neuropathy type 2, genetic disorder, lymphocyte count and reticulocyte count.
How long is the RETREG1 protein?
The Homo sapiens RETREG1 protein (UniProt Q9H6L5) is 497 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6L5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6L5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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