Acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3)
Homo sapiens — UniProt Q9H6R3
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3) is a protein from Homo sapiens identified by UniProt accession Q9H6R3, 686 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q9H6R3; gene symbol ACSS3.
- Organism: Homo sapiens.
- Length: 686 amino acids.
- Top disease associations (Open Targets): alcohol consumption measurement, serum gamma-glutamyl transferase measurement and diet measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-CoA synthetase short-chain family member 3, mitochondrial |
|---|---|
| UniProt accession | Q9H6R3 |
| Gene | ACSS3 |
| Organism | Homo sapiens |
| Length | 686 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- alcohol consumption measurement · score 0.40
- serum gamma-glutamyl transferase measurement · score 0.37
- diet measurement · score 0.28
- gait measurement · score 0.28
- alcohol use disorder measurement · score 0.28
- neoplasm · score 0.08
- bladder transitional cell carcinoma · score 0.07
- type 2 diabetes mellitus · score 0.07
- temporal arteritis · score 0.06
- non-small cell lung carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6R3-F1 | alphafold | PREDICTED | 86.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6R3.
Amino-acid sequence (686 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACSS3?
The strongest Open Targets associations for ACSS3 are alcohol consumption measurement, serum gamma-glutamyl transferase measurement, diet measurement, gait measurement and alcohol use disorder measurement.
How long is the ACSS3 protein?
The Homo sapiens ACSS3 protein (UniProt Q9H6R3) is 686 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6R3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6R3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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