3'-5' RNA helicase YTHDC2 (YTHDC2)
Homo sapiens — UniProt Q9H6S0
Data last refreshed: (UniProt release unknown)
Key facts
3'-5' RNA helicase YTHDC2 (YTHDC2) is a protein from Homo sapiens identified by UniProt accession Q9H6S0, 1430 residues long. MolForge cross-references it against 0 known binders and 270 disease associations.
- UniProt accession: Q9H6S0; gene symbol YTHDC2.
- Organism: Homo sapiens.
- Length: 1430 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, electrocardiography and waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 3'-5' RNA helicase YTHDC2 |
|---|---|
| UniProt accession | Q9H6S0 |
| Gene | YTHDC2 |
| Organism | Homo sapiens |
| Length | 1430 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (270)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- electrocardiography · score 0.27
- waist-hip ratio · score 0.20
- BMI-adjusted waist-hip ratio · score 0.19
- lip morphology measurement · score 0.19
- gut microbiome measurement · score 0.18
- neutrophil percentage of leukocytes · score 0.17
- sudden cardiac arrest · score 0.16
- type 2 diabetes mellitus · score 0.15
- body mass index · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6S0-F1 | alphafold | PREDICTED | 76.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6S0.
Amino-acid sequence (1430 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with YTHDC2?
The strongest Open Targets associations for YTHDC2 are neurodegenerative disease, electrocardiography, waist-hip ratio, BMI-adjusted waist-hip ratio and lip morphology measurement.
How long is the YTHDC2 protein?
The Homo sapiens YTHDC2 protein (UniProt Q9H6S0) is 1430 amino acids long.
Browse: Targets: Y · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6S0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6S0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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