Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2)
Homo sapiens — UniProt Q9H6S3
Data last refreshed: (UniProt release unknown)
Key facts
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) is a protein from Homo sapiens identified by UniProt accession Q9H6S3, 715 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9H6S3; gene symbol EPS8L2.
- Organism: Homo sapiens.
- Length: 715 amino acids.
- Top disease associations (Open Targets): deafness, hearing loss, autosomal recessive and intellectual disability, autosomal dominant 24.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epidermal growth factor receptor kinase substrate 8-like protein 2 |
|---|---|
| UniProt accession | Q9H6S3 |
| Gene | EPS8L2 |
| Organism | Homo sapiens |
| Length | 715 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- deafness · score 0.60
- hearing loss, autosomal recessive · score 0.59
- intellectual disability, autosomal dominant 24 · score 0.41
- genetic disorder · score 0.19
- nonsyndromic genetic hearing loss · score 0.18
- intellectual disability-epilepsy-extrapyramidal syndrome · score 0.18
- intellectual developmental disorder with paroxysmal dyskinesia or seizures · score 0.18
- Meniere disease · score 0.16
- body height · score 0.14
- blood protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6S3-F1 | alphafold | PREDICTED | 73.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6S3.
Amino-acid sequence (715 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EPS8L2?
The strongest Open Targets associations for EPS8L2 are deafness, hearing loss, autosomal recessive, intellectual disability, autosomal dominant 24, genetic disorder and nonsyndromic genetic hearing loss.
How long is the EPS8L2 protein?
The Homo sapiens EPS8L2 protein (UniProt Q9H6S3) is 715 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6S3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6S3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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