Epithelial splicing regulatory protein 2 (ESRP2)
Homo sapiens — UniProt Q9H6T0
Data last refreshed: (UniProt release unknown)
Key facts
Epithelial splicing regulatory protein 2 (ESRP2) is a protein from Homo sapiens identified by UniProt accession Q9H6T0, 727 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q9H6T0; gene symbol ESRP2.
- Organism: Homo sapiens.
- Length: 727 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cleft lip and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epithelial splicing regulatory protein 2 |
|---|---|
| UniProt accession | Q9H6T0 |
| Gene | ESRP2 |
| Organism | Homo sapiens |
| Length | 727 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- cleft lip · score 0.39
- Parkinson disease · score 0.32
- multiple sclerosis · score 0.32
- lysosomal storage disease · score 0.32
- Alzheimer disease · score 0.32
- lung adenocarcinoma · score 0.23
- breast adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.18
- head and neck squamous cell carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6T0-F1 | alphafold | PREDICTED | 73.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6T0.
Amino-acid sequence (727 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ESRP2?
The strongest Open Targets associations for ESRP2 are neurodegenerative disease, cleft lip, Parkinson disease, multiple sclerosis and lysosomal storage disease.
How long is the ESRP2 protein?
The Homo sapiens ESRP2 protein (UniProt Q9H6T0) is 727 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6T0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6T0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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