RNA polymerase II-associated protein 3 (RPAP3)
Homo sapiens — UniProt Q9H6T3
Data last refreshed: (UniProt release unknown)
Key facts
RNA polymerase II-associated protein 3 (RPAP3) is a protein from Homo sapiens identified by UniProt accession Q9H6T3, 665 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9H6T3; gene symbol RPAP3.
- Organism: Homo sapiens.
- Length: 665 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, brain injury and age at menarche.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA polymerase II-associated protein 3 |
|---|---|
| UniProt accession | Q9H6T3 |
| Gene | RPAP3 |
| Organism | Homo sapiens |
| Length | 665 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- brain injury · score 0.20
- age at menarche · score 0.18
- neurofibrillary tangles measurement · score 0.18
- cup-to-disc ratio measurement · score 0.15
- PHF-tau measurement · score 0.14
- lysosomal storage disease · score 0.12
- hypertension · score 0.09
- platelet-to-lymphocyte ratio · score 0.09
- pseudohypoparathyroidism type 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6T3-F1 | alphafold | PREDICTED | 74.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6T3.
Amino-acid sequence (665 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RPAP3?
The strongest Open Targets associations for RPAP3 are neurodegenerative disease, brain injury, age at menarche, neurofibrillary tangles measurement and cup-to-disc ratio measurement.
How long is the RPAP3 protein?
The Homo sapiens RPAP3 protein (UniProt Q9H6T3) is 665 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6T3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6T3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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