Alpha-1,2-mannosyltransferase ALG9 (ALG9)
Homo sapiens — UniProt Q9H6U8
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-1,2-mannosyltransferase ALG9 (ALG9) is a protein from Homo sapiens identified by UniProt accession Q9H6U8, 611 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q9H6U8; gene symbol ALG9.
- Organism: Homo sapiens.
- Length: 611 amino acids.
- Top disease associations (Open Targets): ALG9-congenital disorder of glycosylation, Cystic Kidney Disease and cystic liver disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-1,2-mannosyltransferase ALG9 |
|---|---|
| UniProt accession | Q9H6U8 |
| Gene | ALG9 |
| Organism | Homo sapiens |
| Length | 611 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- ALG9-congenital disorder of glycosylation · score 0.82
- Cystic Kidney Disease · score 0.46
- cystic liver disease · score 0.46
- congenital disorder of glycosylation type I · score 0.46
- neurodegenerative disease · score 0.46
- Autosomal dominant polycystic kidney disease · score 0.42
- kidney disease · score 0.42
- autosomal dominant polycystic liver disease · score 0.38
- Isolated polycystic liver disease · score 0.38
- Global developmental delay · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6U8-F1 | alphafold | PREDICTED | 87.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6U8.
Amino-acid sequence (611 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALG9?
The strongest Open Targets associations for ALG9 are ALG9-congenital disorder of glycosylation, Cystic Kidney Disease, cystic liver disease, congenital disorder of glycosylation type I and neurodegenerative disease.
How long is the ALG9 protein?
The Homo sapiens ALG9 protein (UniProt Q9H6U8) is 611 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6U8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6U8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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