PDZ domain-containing protein MAGIX (MAGIX)
Homo sapiens — UniProt Q9H6Y5
Data last refreshed: (UniProt release unknown)
Key facts
PDZ domain-containing protein MAGIX (MAGIX) is a protein from Homo sapiens identified by UniProt accession Q9H6Y5, 334 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q9H6Y5; gene symbol MAGIX.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): Blackfan-Diamond anemia, thrombocytopenia 4 and macrothrombocytopenia, isolated, 2, autosomal dominant.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PDZ domain-containing protein MAGIX |
|---|---|
| UniProt accession | Q9H6Y5 |
| Gene | MAGIX |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.08
- thrombocytopenia 4 · score 0.07
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.06
- Pyruvate kinase hyperactivity · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- thrombocytopenia 2 · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- alpha-thalassemia-myelodysplastic syndrome · score 0.06
- platelet-type bleeding disorder 10 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6Y5-F1 | alphafold | PREDICTED | 61.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6Y5.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAGIX?
The strongest Open Targets associations for MAGIX are Blackfan-Diamond anemia, thrombocytopenia 4, macrothrombocytopenia, isolated, 2, autosomal dominant, beta-thalassemia-X-linked thrombocytopenia syndrome and Pyruvate kinase hyperactivity.
How long is the MAGIX protein?
The Homo sapiens MAGIX protein (UniProt Q9H6Y5) is 334 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6Y5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6Y5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.