GRB2-associated and regulator of MAPK protein 1 (GAREM1)
Homo sapiens — UniProt Q9H706
Data last refreshed: (UniProt release unknown)
Key facts
GRB2-associated and regulator of MAPK protein 1 (GAREM1) is a protein from Homo sapiens identified by UniProt accession Q9H706, 876 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q9H706; gene symbol GAREM1.
- Organism: Homo sapiens.
- Length: 876 amino acids.
- Top disease associations (Open Targets): neurofibrillary tangles measurement, breast carcinoma and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GRB2-associated and regulator of MAPK protein 1 |
|---|---|
| UniProt accession | Q9H706 |
| Gene | GAREM1 |
| Organism | Homo sapiens |
| Length | 876 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.41
- breast carcinoma · score 0.41
- PR interval · score 0.38
- PHF-tau measurement · score 0.34
- resting heart rate · score 0.30
- diet measurement · score 0.29
- blood protein measurement · score 0.28
- left ventricular systolic function measurement · score 0.27
- left ventricular diastolic function measurement · score 0.27
- sitting height measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H706-F1 | alphafold | PREDICTED | 58.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H706.
Amino-acid sequence (876 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GAREM1?
The strongest Open Targets associations for GAREM1 are neurofibrillary tangles measurement, breast carcinoma, PR interval, PHF-tau measurement and resting heart rate.
How long is the GAREM1 protein?
The Homo sapiens GAREM1 protein (UniProt Q9H706) is 876 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H706 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H706 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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