SREBP regulating gene protein (SPRING1)
Homo sapiens — UniProt Q9H741
Data last refreshed: (UniProt release unknown)
Key facts
SREBP regulating gene protein (SPRING1) is a protein from Homo sapiens identified by UniProt accession Q9H741, 205 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9H741; gene symbol SPRING1.
- Organism: Homo sapiens.
- Length: 205 amino acids.
- Top disease associations (Open Targets): apolipoprotein A 1 measurement, neuroticism measurement and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SREBP regulating gene protein |
|---|---|
| UniProt accession | Q9H741 |
| Gene | SPRING1 |
| Organism | Homo sapiens |
| Length | 205 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.41
- neuroticism measurement · score 0.39
- high density lipoprotein cholesterol measurement · score 0.37
- gut microbiome measurement · score 0.31
- worry measurement · score 0.30
- hippocampal volume · score 0.07
- eosinophil count · score 0.06
- neoplasm · score 0.05
- brain volume measurement · score 0.05
- pulse pressure measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H741-F1 | alphafold | PREDICTED | 81.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H741.
Amino-acid sequence (205 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPRING1?
The strongest Open Targets associations for SPRING1 are apolipoprotein A 1 measurement, neuroticism measurement, high density lipoprotein cholesterol measurement, gut microbiome measurement and worry measurement.
How long is the SPRING1 protein?
The Homo sapiens SPRING1 protein (UniProt Q9H741) is 205 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H741 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H741 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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