Gremlin-2 (GREM2)
Homo sapiens — UniProt Q9H772
Data last refreshed: (UniProt release unknown)
Key facts
Gremlin-2 (GREM2) is a protein from Homo sapiens identified by UniProt accession Q9H772, 168 residues long. MolForge cross-references it against 0 known binders and 403 disease associations.
- UniProt accession: Q9H772; gene symbol GREM2.
- Organism: Homo sapiens.
- Length: 168 amino acids.
- Top disease associations (Open Targets): tooth agenesis, heel bone mineral density and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gremlin-2 |
|---|---|
| UniProt accession | Q9H772 |
| Gene | GREM2 |
| Organism | Homo sapiens |
| Length | 168 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (403)
Diseases linked to this target (Open Targets).
- tooth agenesis · score 0.62
- heel bone mineral density · score 0.47
- FEV/FVC ratio · score 0.35
- cervical disc degenerative disorder · score 0.25
- bone density · score 0.20
- bone quantitative ultrasound measurement · score 0.19
- platelet count · score 0.17
- alkaline phosphatase measurement · score 0.17
- Drugs affecting bone structure and mineralization use measurement · score 0.16
- bone disease · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H772-F1 | alphafold | PREDICTED | 79.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H772.
Amino-acid sequence (168 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GREM2?
The strongest Open Targets associations for GREM2 are tooth agenesis, heel bone mineral density, FEV/FVC ratio, cervical disc degenerative disorder and bone density.
How long is the GREM2 protein?
The Homo sapiens GREM2 protein (UniProt Q9H772) is 168 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H772 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H772 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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