Zinc phosphodiesterase ELAC protein 1 (ELAC1)
Homo sapiens — UniProt Q9H777
Data last refreshed: (UniProt release unknown)
Key facts
Zinc phosphodiesterase ELAC protein 1 (ELAC1) is a protein from Homo sapiens identified by UniProt accession Q9H777, 363 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9H777; gene symbol ELAC1.
- Organism: Homo sapiens.
- Length: 363 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, eosinophil count and eosinophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc phosphodiesterase ELAC protein 1 |
|---|---|
| UniProt accession | Q9H777 |
| Gene | ELAC1 |
| Organism | Homo sapiens |
| Length | 363 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- eosinophil count · score 0.18
- eosinophil percentage of leukocytes · score 0.05
- Eczematoid dermatitis · score 0.04
- childhood onset asthma · score 0.04
- asthma · score 0.04
- apolipoprotein A 1 measurement · score 0.04
- allergic rhinitis · score 0.03
- platelet count · score 0.03
- platelet crit · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H777-F1 | alphafold | PREDICTED | 91.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H777.
Amino-acid sequence (363 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ELAC1?
The strongest Open Targets associations for ELAC1 are neurodegenerative disease, eosinophil count, eosinophil percentage of leukocytes, Eczematoid dermatitis and childhood onset asthma.
How long is the ELAC1 protein?
The Homo sapiens ELAC1 protein (UniProt Q9H777) is 363 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H777 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H777 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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