SH2 domain-containing protein 4A (SH2D4A)
Homo sapiens — UniProt Q9H788
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing protein 4A (SH2D4A) is a protein from Homo sapiens identified by UniProt accession Q9H788, 454 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q9H788; gene symbol SH2D4A.
- Organism: Homo sapiens.
- Length: 454 amino acids.
- Top disease associations (Open Targets): insulin measurement, urate measurement and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing protein 4A |
|---|---|
| UniProt accession | Q9H788 |
| Gene | SH2D4A |
| Organism | Homo sapiens |
| Length | 454 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- insulin measurement · score 0.28
- urate measurement · score 0.25
- heel bone mineral density · score 0.21
- bone density · score 0.15
- body height · score 0.12
- sitting height measurement · score 0.10
- forced expiratory volume · score 0.10
- self reported educational attainment · score 0.10
- vesicoureteral reflux · score 0.10
- mean platelet volume · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H788-F1 | alphafold | PREDICTED | 73.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H788.
Amino-acid sequence (454 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH2D4A?
The strongest Open Targets associations for SH2D4A are insulin measurement, urate measurement, heel bone mineral density, bone density and body height.
How long is the SH2D4A protein?
The Homo sapiens SH2D4A protein (UniProt Q9H788) is 454 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H788 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H788 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.