Exonuclease V (EXO5)
Homo sapiens — UniProt Q9H790
Data last refreshed: (UniProt release unknown)
Key facts
Exonuclease V (EXO5) is a protein from Homo sapiens identified by UniProt accession Q9H790, 373 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q9H790; gene symbol EXO5.
- Organism: Homo sapiens.
- Length: 373 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and spermatogenic failure 8.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exonuclease V |
|---|---|
| UniProt accession | Q9H790 |
| Gene | EXO5 |
| Organism | Homo sapiens |
| Length | 373 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 8 · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 1 · score 0.07
- spermatogenic failure 22 · score 0.06
- spermatogenic failure 48 · score 0.06
- spermatogenic failure 51 · score 0.06
- spermatogenic failure 40 · score 0.06
- spermatogenic failure, X-linked, 3 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H790-F1 | alphafold | PREDICTED | 79.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H790.
Amino-acid sequence (373 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXO5?
The strongest Open Targets associations for EXO5 are azoospermia, male infertility with teratozoospermia due to single gene mutation, spermatogenic failure 8, partial chromosome Y deletion and spermatogenic failure 1.
How long is the EXO5 protein?
The Homo sapiens EXO5 protein (UniProt Q9H790) is 373 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H790 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H790 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.