Histone-lysine N-methyltransferase SMYD3 (SMYD3)
Homo sapiens — UniProt Q9H7B4
Data last refreshed: (UniProt release unknown)
Key facts
Histone-lysine N-methyltransferase SMYD3 (SMYD3) is a protein from Homo sapiens identified by UniProt accession Q9H7B4, 428 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.
- UniProt accession: Q9H7B4; gene symbol SMYD3.
- Organism: Homo sapiens.
- Length: 428 amino acids.
- Top disease associations (Open Targets): electrocardiography, diffuse plaque measurement and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone-lysine N-methyltransferase SMYD3 |
|---|---|
| UniProt accession | Q9H7B4 |
| Gene | SMYD3 |
| Organism | Homo sapiens |
| Length | 428 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (161)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.37
- diffuse plaque measurement · score 0.35
- PR interval · score 0.35
- protein measurement · score 0.30
- PHF-tau measurement · score 0.28
- breast adenocarcinoma · score 0.24
- systemic lupus erythematosus · score 0.24
- metabolite measurement · score 0.24
- Cognitive impairment · score 0.24
- Primary amenorrhea · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7B4-F1 | alphafold | PREDICTED | 97.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7B4.
Amino-acid sequence (428 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMYD3?
The strongest Open Targets associations for SMYD3 are electrocardiography, diffuse plaque measurement, PR interval, protein measurement and PHF-tau measurement.
How long is the SMYD3 protein?
The Homo sapiens SMYD3 protein (UniProt Q9H7B4) is 428 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7B4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7B4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.