Dedicator of cytokinesis protein 5 (DOCK5)

Homo sapiens — UniProt Q9H7D0

Gene: DOCK5Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Dedicator of cytokinesis protein 5 (DOCK5) is a protein from Homo sapiens identified by UniProt accession Q9H7D0, 1870 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

UniProt accession: Q9H7D0; gene symbol DOCK5.
Organism: Homo sapiens.
Length: 1870 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, platelet component distribution width and mean platelet volume.
3D structure: AlphaFold model available.

Target properties

Protein name	Dedicator of cytokinesis protein 5
UniProt accession	Q9H7D0
Gene	DOCK5
Organism	Homo sapiens
Length	1870 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
platelet component distribution width · score 0.38
mean platelet volume · score 0.27
protein measurement · score 0.24
bone density · score 0.24
coronary artery disease · score 0.20
ovarian cancer · score 0.18
low grade glioma · score 0.18
breast adenocarcinoma · score 0.18
pancreatic adenocarcinoma · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H7D0-F1	alphafold	PREDICTED	78.95	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7D0.

Amino-acid sequence (1870 residues)

MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL QNKSKKGIFP ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV IWRKLYVNNK LTLFRQLQQM TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST IALFKAHEVA SKRIEEKIQE EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE LFMALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ IAMETYIRQR QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL EKAIHPGAGY EGISEYKSVV YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR DKSERAFGVA FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI KHNLKKLMEV DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI YKHFSATLAY VKLSKVLNFY VANADDSSKT ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ SKDGDEFNNS IRQLFLAFNM LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF CKFIQSIPDN QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI GSFVACMIAL LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQNRVFLRA INQFAEVLTR FFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSQAKRN KIVKKYGDMR KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HRDCENYTEA AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL SKELAETYES KVFDYEGLGN LLKKRASFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI FIYRGKEYER REDFSLRLLT QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS YKDKPVPEQI LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML LSGIVDPAVM GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL TEGIRIHGEK LTEQLKPLHE RLSSCFRELK EKVEKHYGVI TLPPNLTERK QSRTGSIVLP YIMSSTLRRL SITSVTSSVV STSSNSSDNA PSRPGSDGSI LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS KSQVIAEKAP EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP PPPPPKARKS GIPTSEPGSQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with DOCK5?

The strongest Open Targets associations for DOCK5 are neurodegenerative disease, platelet component distribution width, mean platelet volume, protein measurement and bone density.

How long is the DOCK5 protein?

The Homo sapiens DOCK5 protein (UniProt Q9H7D0) is 1870 amino acids long.

Browse: Targets: D · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9H7D0 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9H7D0 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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