Transmembrane protein 185B (TMEM185B)
Homo sapiens — UniProt Q9H7F4
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 185B (TMEM185B) is a protein from Homo sapiens identified by UniProt accession Q9H7F4, 350 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9H7F4; gene symbol TMEM185B.
- Organism: Homo sapiens.
- Length: 350 amino acids.
- Top disease associations (Open Targets): reticulocyte measurement, platelet crit and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 185B |
|---|---|
| UniProt accession | Q9H7F4 |
| Gene | TMEM185B |
| Organism | Homo sapiens |
| Length | 350 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- reticulocyte measurement · score 0.28
- platelet crit · score 0.11
- glomerular filtration rate · score 0.11
- reticulocyte count · score 0.10
- low density lipoprotein cholesterol measurement · score 0.08
- urate measurement · score 0.08
- creatinine measurement · score 0.08
- neurodegenerative disease · score 0.08
- mathematical ability · score 0.08
- serum urea measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7F4-F1 | alphafold | PREDICTED | 78.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7F4.
Amino-acid sequence (350 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM185B?
The strongest Open Targets associations for TMEM185B are reticulocyte measurement, platelet crit, glomerular filtration rate, reticulocyte count and low density lipoprotein cholesterol measurement.
How long is the TMEM185B protein?
The Homo sapiens TMEM185B protein (UniProt Q9H7F4) is 350 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7F4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7F4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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