V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Homo sapiens — UniProt Q9H7M9
Data last refreshed: (UniProt release unknown)
Key facts
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) is a protein from Homo sapiens identified by UniProt accession Q9H7M9, 311 residues long. MolForge cross-references it against 0 known binders and 332 disease associations.
- UniProt accession: Q9H7M9; gene symbol VSIR.
- Organism: Homo sapiens.
- Length: 311 amino acids.
- Top disease associations (Open Targets): monocyte count, leukocyte count and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | V-type immunoglobulin domain-containing suppressor of T-cell activation |
|---|---|
| UniProt accession | Q9H7M9 |
| Gene | VSIR |
| Organism | Homo sapiens |
| Length | 311 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (332)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.45
- leukocyte count · score 0.44
- neutrophil count · score 0.43
- myeloid white cell count · score 0.41
- lymphocyte count · score 0.38
- lymphocyte percentage of leukocytes · score 0.34
- blood protein measurement · score 0.32
- neutrophil percentage of leukocytes · score 0.31
- Red cell distribution width · score 0.31
- C-X-C motif chemokine 16 measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7M9-F1 | alphafold | PREDICTED | 73.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7M9.
Amino-acid sequence (311 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VSIR?
The strongest Open Targets associations for VSIR are monocyte count, leukocyte count, neutrophil count, myeloid white cell count and lymphocyte count.
How long is the VSIR protein?
The Homo sapiens VSIR protein (UniProt Q9H7M9) is 311 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7M9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7M9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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