Pleckstrin homology domain-containing family G member 2 (PLEKHG2)
Homo sapiens — UniProt Q9H7P9
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family G member 2 (PLEKHG2) is a protein from Homo sapiens identified by UniProt accession Q9H7P9, 1386 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9H7P9; gene symbol PLEKHG2.
- Organism: Homo sapiens.
- Length: 1386 amino acids.
- Top disease associations (Open Targets): leukodystrophy and acquired microcephaly with or without dystonia;, Abnormal brain morphology and pancreatic adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family G member 2 |
|---|---|
| UniProt accession | Q9H7P9 |
| Gene | PLEKHG2 |
| Organism | Homo sapiens |
| Length | 1386 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- leukodystrophy and acquired microcephaly with or without dystonia; · score 0.63
- Abnormal brain morphology · score 0.27
- pancreatic adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- neuroblastoma · score 0.11
- Microcephaly · score 0.11
- glioblastoma multiforme · score 0.11
- non-small cell lung carcinoma · score 0.07
- neutrophil count · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7P9-F1 | alphafold | PREDICTED | 47.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7P9.
Amino-acid sequence (1386 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHG2?
The strongest Open Targets associations for PLEKHG2 are leukodystrophy and acquired microcephaly with or without dystonia;, Abnormal brain morphology, pancreatic adenocarcinoma, breast adenocarcinoma and neuroblastoma.
How long is the PLEKHG2 protein?
The Homo sapiens PLEKHG2 protein (UniProt Q9H7P9) is 1386 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7P9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7P9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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