Nuclear exosome regulator NRDE2 (NRDE2)
Homo sapiens — UniProt Q9H7Z3
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear exosome regulator NRDE2 (NRDE2) is a protein from Homo sapiens identified by UniProt accession Q9H7Z3, 1164 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q9H7Z3; gene symbol NRDE2.
- Organism: Homo sapiens.
- Length: 1164 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss, gut microbiome measurement and taxonomic microbiome measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear exosome regulator NRDE2 |
|---|---|
| UniProt accession | Q9H7Z3 |
| Gene | NRDE2 |
| Organism | Homo sapiens |
| Length | 1164 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss · score 0.33
- gut microbiome measurement · score 0.30
- taxonomic microbiome measurement · score 0.29
- Neurodevelopmental disorder · score 0.12
- metabolite measurement · score 0.10
- hepatocellular carcinoma · score 0.08
- Age-related cataract · score 0.06
- neoplasm · score 0.06
- MODY · score 0.06
- body height · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7Z3-F1 | alphafold | PREDICTED | 72.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7Z3.
Amino-acid sequence (1164 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NRDE2?
The strongest Open Targets associations for NRDE2 are neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss, gut microbiome measurement, taxonomic microbiome measurement, Neurodevelopmental disorder and metabolite measurement.
How long is the NRDE2 protein?
The Homo sapiens NRDE2 protein (UniProt Q9H7Z3) is 1164 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7Z3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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