Histone acetyltransferase KAT8 (KAT8)
Homo sapiens — UniProt Q9H7Z6
Data last refreshed: (UniProt release unknown)
Key facts
Histone acetyltransferase KAT8 (KAT8) is a protein from Homo sapiens identified by UniProt accession Q9H7Z6, 458 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.
- UniProt accession: Q9H7Z6; gene symbol KAT8.
- Organism: Homo sapiens.
- Length: 458 amino acids.
- Top disease associations (Open Targets): Li-Ghorbani-Weisz-Hubshman syndrome, Alzheimer disease and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone acetyltransferase KAT8 |
|---|---|
| UniProt accession | Q9H7Z6 |
| Gene | KAT8 |
| Organism | Homo sapiens |
| Length | 458 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (150)
Diseases linked to this target (Open Targets).
- Li-Ghorbani-Weisz-Hubshman syndrome · score 0.67
- Alzheimer disease · score 0.49
- Parkinson disease · score 0.49
- Intellectual disability · score 0.47
- lysosomal storage disease · score 0.46
- Autism · score 0.46
- Global developmental delay · score 0.46
- Abnormality of vision · score 0.46
- autism · score 0.46
- Abnormality of the cardiovascular system · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7Z6-F1 | alphafold | PREDICTED | 81.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7Z6.
Amino-acid sequence (458 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KAT8?
The strongest Open Targets associations for KAT8 are Li-Ghorbani-Weisz-Hubshman syndrome, Alzheimer disease, Parkinson disease, Intellectual disability and lysosomal storage disease.
How long is the KAT8 protein?
The Homo sapiens KAT8 protein (UniProt Q9H7Z6) is 458 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7Z6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7Z6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.