Prostaglandin E synthase 2 (PTGES2)
Homo sapiens — UniProt Q9H7Z7
Data last refreshed: (UniProt release unknown)
Key facts
Prostaglandin E synthase 2 (PTGES2) is a protein from Homo sapiens identified by UniProt accession Q9H7Z7, 377 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q9H7Z7; gene symbol PTGES2.
- Organism: Homo sapiens.
- Length: 377 amino acids.
- Top disease associations (Open Targets): blood protein measurement, neutrophil count and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prostaglandin E synthase 2 |
|---|---|
| UniProt accession | Q9H7Z7 |
| Gene | PTGES2 |
| Organism | Homo sapiens |
| Length | 377 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.35
- neutrophil count · score 0.14
- genetic disorder · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- low grade glioma · score 0.10
- skin basal cell carcinoma · score 0.07
- acute kidney failure · score 0.05
- hepatocellular carcinoma · score 0.05
- lymphatic malformation 3 · score 0.04
- essential thrombocythemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H7Z7-F1 | alphafold | PREDICTED | 83.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H7Z7.
Amino-acid sequence (377 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTGES2?
The strongest Open Targets associations for PTGES2 are blood protein measurement, neutrophil count, genetic disorder, head and neck squamous cell carcinoma and low grade glioma.
How long is the PTGES2 protein?
The Homo sapiens PTGES2 protein (UniProt Q9H7Z7) is 377 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H7Z7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H7Z7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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