Transducin-like enhancer protein 6 (TLE6)
Homo sapiens — UniProt Q9H808
Data last refreshed: (UniProt release unknown)
Key facts
Transducin-like enhancer protein 6 (TLE6) is a protein from Homo sapiens identified by UniProt accession Q9H808, 572 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9H808; gene symbol TLE6.
- Organism: Homo sapiens.
- Length: 572 amino acids.
- Top disease associations (Open Targets): Rare genetic female infertility, Female infertility due to fertilization defect and female infertility due to oocyte meiotic arrest.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transducin-like enhancer protein 6 |
|---|---|
| UniProt accession | Q9H808 |
| Gene | TLE6 |
| Organism | Homo sapiens |
| Length | 572 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- Rare genetic female infertility · score 0.71
- Female infertility due to fertilization defect · score 0.05
- female infertility due to oocyte meiotic arrest · score 0.04
- premature ovarian failure 19 · score 0.04
- oocyte maturation defect 9 · score 0.04
- neoplasm · score 0.03
- oocyte/zygote/embryo maturation arrest 17 · score 0.03
- glioblastoma multiforme · score 0.03
- Posterior Leukoencephalopathy Syndrome · score 0.02
- female infertility · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H808-F1 | alphafold | PREDICTED | 66.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H808.
Amino-acid sequence (572 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TLE6?
The strongest Open Targets associations for TLE6 are Rare genetic female infertility, Female infertility due to fertilization defect, female infertility due to oocyte meiotic arrest, premature ovarian failure 19 and oocyte maturation defect 9.
How long is the TLE6 protein?
The Homo sapiens TLE6 protein (UniProt Q9H808) is 572 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H808 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H808 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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