Proton-activated chloride channel (PACC1)
Homo sapiens — UniProt Q9H813
Data last refreshed: (UniProt release unknown)
Key facts
Proton-activated chloride channel (PACC1) is a protein from Homo sapiens identified by UniProt accession Q9H813, 350 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.
- UniProt accession: Q9H813; gene symbol PACC1.
- Organism: Homo sapiens.
- Length: 350 amino acids.
- Top disease associations (Open Targets): monocyte count, basophil count and basophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proton-activated chloride channel |
|---|---|
| UniProt accession | Q9H813 |
| Gene | PACC1 |
| Organism | Homo sapiens |
| Length | 350 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.42
- basophil count · score 0.41
- basophil percentage of leukocytes · score 0.36
- body height · score 0.31
- self reported educational attainment · score 0.21
- basophil percentage of granulocytes · score 0.20
- BMI-adjusted waist-hip ratio · score 0.19
- sitting height measurement · score 0.14
- monocyte percentage of leukocytes · score 0.14
- high density lipoprotein cholesterol measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H813-F1 | alphafold | PREDICTED | 78.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H813.
Amino-acid sequence (350 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PACC1?
The strongest Open Targets associations for PACC1 are monocyte count, basophil count, basophil percentage of leukocytes, body height and self reported educational attainment.
How long is the PACC1 protein?
The Homo sapiens PACC1 protein (UniProt Q9H813) is 350 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H813 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H813 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.