Phosphorylated adapter RNA export protein (PHAX)
Homo sapiens — UniProt Q9H814
Data last refreshed: (UniProt release unknown)
Key facts
Phosphorylated adapter RNA export protein (PHAX) is a protein from Homo sapiens identified by UniProt accession Q9H814, 394 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q9H814; gene symbol PHAX.
- Organism: Homo sapiens.
- Length: 394 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, adult-onset autosomal dominant demyelinating leukodystrophy and Adult-onset autosomal dominant leukodystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphorylated adapter RNA export protein |
|---|---|
| UniProt accession | Q9H814 |
| Gene | PHAX |
| Organism | Homo sapiens |
| Length | 394 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- adult-onset autosomal dominant demyelinating leukodystrophy · score 0.34
- Adult-onset autosomal dominant leukodystrophy · score 0.34
- Hirschsprung disease · score 0.11
- Aganglionic megacolon · score 0.11
- nonpapillary renal cell carcinoma · score 0.07
- neoplasm · score 0.06
- hematocrit · score 0.04
- hemoglobin measurement · score 0.04
- colorectal cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H814-F1 | alphafold | PREDICTED | 65.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H814.
Amino-acid sequence (394 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHAX?
The strongest Open Targets associations for PHAX are neurodegenerative disease, adult-onset autosomal dominant demyelinating leukodystrophy, Adult-onset autosomal dominant leukodystrophy, Hirschsprung disease and Aganglionic megacolon.
How long is the PHAX protein?
The Homo sapiens PHAX protein (UniProt Q9H814) is 394 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H814 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H814 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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