5' exonuclease Apollo (DCLRE1B)
Homo sapiens — UniProt Q9H816
Data last refreshed: (UniProt release unknown)
Key facts
5' exonuclease Apollo (DCLRE1B) is a protein from Homo sapiens identified by UniProt accession Q9H816, 532 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q9H816; gene symbol DCLRE1B.
- Organism: Homo sapiens.
- Length: 532 amino acids.
- Top disease associations (Open Targets): telomere length, Fanconi anemia complementation group C and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5' exonuclease Apollo |
|---|---|
| UniProt accession | Q9H816 |
| Gene | DCLRE1B |
| Organism | Homo sapiens |
| Length | 532 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- telomere length · score 0.59
- Fanconi anemia complementation group C · score 0.43
- breast carcinoma · score 0.36
- neoplasm · score 0.27
- type 1 diabetes mellitus · score 0.26
- neurodegenerative disease · score 0.26
- coronary artery disease · score 0.25
- myocardial infarction · score 0.25
- autoimmune thyroid disease · score 0.25
- Hoyeraal-Hreidarsson syndrome · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H816-F1 | alphafold | PREDICTED | 74.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H816.
Amino-acid sequence (532 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCLRE1B?
The strongest Open Targets associations for DCLRE1B are telomere length, Fanconi anemia complementation group C, breast carcinoma, neoplasm and type 1 diabetes mellitus.
How long is the DCLRE1B protein?
The Homo sapiens DCLRE1B protein (UniProt Q9H816) is 532 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H816 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H816 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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