tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial (METTL8)
Homo sapiens — UniProt Q9H825
Data last refreshed: (UniProt release unknown)
Key facts
tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial (METTL8) is a protein from Homo sapiens identified by UniProt accession Q9H825, 291 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9H825; gene symbol METTL8.
- Organism: Homo sapiens.
- Length: 291 amino acids.
- Top disease associations (Open Targets): Woodhouse-Sakati syndrome, body height and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial |
|---|---|
| UniProt accession | Q9H825 |
| Gene | METTL8 |
| Organism | Homo sapiens |
| Length | 291 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- Woodhouse-Sakati syndrome · score 0.52
- body height · score 0.34
- BMI-adjusted hip circumference · score 0.23
- appendicular lean mass · score 0.21
- forced expiratory volume · score 0.21
- genetic disorder · score 0.15
- glioblastoma multiforme · score 0.07
- breast cancer · score 0.07
- cancer · score 0.04
- whole body water mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H825-F1 | alphafold | PREDICTED | 73.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H825.
Amino-acid sequence (291 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL8?
The strongest Open Targets associations for METTL8 are Woodhouse-Sakati syndrome, body height, BMI-adjusted hip circumference, appendicular lean mass and forced expiratory volume.
How long is the METTL8 protein?
The Homo sapiens METTL8 protein (UniProt Q9H825) is 291 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H825 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H825 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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