Ubiquitin-conjugating enzyme E2 Z (UBE2Z)
Homo sapiens — UniProt Q9H832
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin-conjugating enzyme E2 Z (UBE2Z) is a protein from Homo sapiens identified by UniProt accession Q9H832, 354 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q9H832; gene symbol UBE2Z.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): platelet count, platelet crit and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 Z |
|---|---|
| UniProt accession | Q9H832 |
| Gene | UBE2Z |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- platelet count · score 0.23
- platelet crit · score 0.21
- body height · score 0.20
- neutrophil percentage of leukocytes · score 0.20
- type 2 diabetes mellitus · score 0.19
- self reported educational attainment · score 0.18
- bilirubin measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.16
- gastric carcinoma · score 0.15
- coronary artery disease · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H832-F1 | alphafold | PREDICTED | 79.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H832.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBE2Z?
The strongest Open Targets associations for UBE2Z are platelet count, platelet crit, body height, neutrophil percentage of leukocytes and type 2 diabetes mellitus.
How long is the UBE2Z protein?
The Homo sapiens UBE2Z protein (UniProt Q9H832) is 354 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H832 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H832 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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