5'-nucleotidase domain-containing protein 2 (NT5DC2)
Homo sapiens — UniProt Q9H857
Data last refreshed: (UniProt release unknown)
Key facts
5'-nucleotidase domain-containing protein 2 (NT5DC2) is a protein from Homo sapiens identified by UniProt accession Q9H857, 520 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.
- UniProt accession: Q9H857; gene symbol NT5DC2.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): hemoglobin measurement, hematocrit and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5'-nucleotidase domain-containing protein 2 |
|---|---|
| UniProt accession | Q9H857 |
| Gene | NT5DC2 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (143)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.34
- hematocrit · score 0.31
- BMI-adjusted waist-hip ratio · score 0.27
- intelligence · score 0.24
- mean corpuscular hemoglobin concentration · score 0.23
- cortical surface area measurement · score 0.23
- brain measurement · score 0.22
- BMI-adjusted waist circumference · score 0.22
- cortical thickness · score 0.21
- age at menarche · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H857-F1 | alphafold | PREDICTED | 86.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H857.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NT5DC2?
The strongest Open Targets associations for NT5DC2 are hemoglobin measurement, hematocrit, BMI-adjusted waist-hip ratio, intelligence and mean corpuscular hemoglobin concentration.
How long is the NT5DC2 protein?
The Homo sapiens NT5DC2 protein (UniProt Q9H857) is 520 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H857 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H857 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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