Protein N-lysine methyltransferase METTL21D (VCPKMT)
Homo sapiens — UniProt Q9H867
Data last refreshed: (UniProt release unknown)
Key facts
Protein N-lysine methyltransferase METTL21D (VCPKMT) is a protein from Homo sapiens identified by UniProt accession Q9H867, 229 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q9H867; gene symbol VCPKMT.
- Organism: Homo sapiens.
- Length: 229 amino acids.
- Top disease associations (Open Targets): arterial stiffness measurement, serum alanine aminotransferase measurement and aspartate aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein N-lysine methyltransferase METTL21D |
|---|---|
| UniProt accession | Q9H867 |
| Gene | VCPKMT |
| Organism | Homo sapiens |
| Length | 229 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- arterial stiffness measurement · score 0.23
- serum alanine aminotransferase measurement · score 0.19
- aspartate aminotransferase measurement · score 0.19
- creatinine measurement · score 0.18
- PHF-tau measurement · score 0.18
- DNA methylation · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.13
- bone density · score 0.13
- urate measurement · score 0.13
- hyperinsulinism due to INSR deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H867-F1 | alphafold | PREDICTED | 92.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H867.
Amino-acid sequence (229 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VCPKMT?
The strongest Open Targets associations for VCPKMT are arterial stiffness measurement, serum alanine aminotransferase measurement, aspartate aminotransferase measurement, creatinine measurement and PHF-tau measurement.
How long is the VCPKMT protein?
The Homo sapiens VCPKMT protein (UniProt Q9H867) is 229 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H867 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H867 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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