Cysteine-rich protein 2-binding protein (KAT14)
Homo sapiens — UniProt Q9H8E8
Data last refreshed: (UniProt release unknown)
Key facts
Cysteine-rich protein 2-binding protein (KAT14) is a protein from Homo sapiens identified by UniProt accession Q9H8E8, 782 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q9H8E8; gene symbol KAT14.
- Organism: Homo sapiens.
- Length: 782 amino acids.
- Top disease associations (Open Targets): mitochondrial complex 4 deficiency, nuclear type 19, Seizure and Global developmental delay.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cysteine-rich protein 2-binding protein |
|---|---|
| UniProt accession | Q9H8E8 |
| Gene | KAT14 |
| Organism | Homo sapiens |
| Length | 782 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- mitochondrial complex 4 deficiency, nuclear type 19 · score 0.27
- Seizure · score 0.27
- Global developmental delay · score 0.27
- Fuchs endothelial corneal dystrophy · score 0.07
- X-linked endothelial corneal dystrophy · score 0.07
- X-linked corneal dermoid · score 0.06
- granular corneal dystrophy type I · score 0.06
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.06
- Cataract-microcornea syndrome · score 0.05
- Schnyder corneal dystrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8E8-F1 | alphafold | PREDICTED | 66.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8E8.
Amino-acid sequence (782 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KAT14?
The strongest Open Targets associations for KAT14 are mitochondrial complex 4 deficiency, nuclear type 19, Seizure, Global developmental delay, Fuchs endothelial corneal dystrophy and X-linked endothelial corneal dystrophy.
How long is the KAT14 protein?
The Homo sapiens KAT14 protein (UniProt Q9H8E8) is 782 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8E8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8E8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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