ATP-dependent DNA helicase DDX31 (DDX31)
Homo sapiens — UniProt Q9H8H2
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent DNA helicase DDX31 (DDX31) is a protein from Homo sapiens identified by UniProt accession Q9H8H2, 851 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q9H8H2; gene symbol DDX31.
- Organism: Homo sapiens.
- Length: 851 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, neurofibrillary tangles measurement and age at menopause.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent DNA helicase DDX31 |
|---|---|
| UniProt accession | Q9H8H2 |
| Gene | DDX31 |
| Organism | Homo sapiens |
| Length | 851 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.28
- neurofibrillary tangles measurement · score 0.25
- age at menopause · score 0.19
- platelet component distribution width · score 0.14
- angiopoietin-1 receptor measurement · score 0.05
- erythrocyte count · score 0.03
- medulloblastoma · score 0.01
- Sepsis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8H2-F1 | alphafold | PREDICTED | 66.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8H2.
Amino-acid sequence (851 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX31?
The strongest Open Targets associations for DDX31 are self reported educational attainment, neurofibrillary tangles measurement, age at menopause, platelet component distribution width and angiopoietin-1 receptor measurement.
How long is the DDX31 protein?
The Homo sapiens DDX31 protein (UniProt Q9H8H2) is 851 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8H2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8H2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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