Thiol S-methyltransferase TMT1A (TMT1A)
Homo sapiens — UniProt Q9H8H3
Data last refreshed: (UniProt release unknown)
Key facts
Thiol S-methyltransferase TMT1A (TMT1A) is a protein from Homo sapiens identified by UniProt accession Q9H8H3, 244 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q9H8H3; gene symbol TMT1A.
- Organism: Homo sapiens.
- Length: 244 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, appendicular lean mass and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thiol S-methyltransferase TMT1A |
|---|---|
| UniProt accession | Q9H8H3 |
| Gene | TMT1A |
| Organism | Homo sapiens |
| Length | 244 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.27
- appendicular lean mass · score 0.13
- lung adenocarcinoma · score 0.10
- cancer · score 0.10
- neoplasm · score 0.10
- renal carcinoma · score 0.07
- melanoma · score 0.07
- hepatocellular carcinoma · score 0.05
- mean corpuscular hemoglobin concentration · score 0.05
- eosinophil count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8H3-F1 | alphafold | PREDICTED | 96.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8H3.
Amino-acid sequence (244 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMT1A?
The strongest Open Targets associations for TMT1A are heel bone mineral density, appendicular lean mass, lung adenocarcinoma, cancer and neoplasm.
How long is the TMT1A protein?
The Homo sapiens TMT1A protein (UniProt Q9H8H3) is 244 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8H3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8H3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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