Metal transporter CNNM2 (CNNM2)
Homo sapiens — UniProt Q9H8M5
Data last refreshed: (UniProt release unknown)
Key facts
Metal transporter CNNM2 (CNNM2) is a protein from Homo sapiens identified by UniProt accession Q9H8M5, 875 residues long. MolForge cross-references it against 0 known binders and 241 disease associations.
- UniProt accession: Q9H8M5; gene symbol CNNM2.
- Organism: Homo sapiens.
- Length: 875 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): familial primary hypomagnesemia with normocalciuria and normocalcemia, hypomagnesemia, seizures, and intellectual disability and Autosomal dominant primary hypomagnesemia with hypocalciuria.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Metal transporter CNNM2 |
|---|---|
| UniProt accession | Q9H8M5 |
| Gene | CNNM2 |
| Organism | Homo sapiens |
| Length | 875 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (241)
Diseases linked to this target (Open Targets).
- familial primary hypomagnesemia with normocalciuria and normocalcemia · score 0.70
- hypomagnesemia, seizures, and intellectual disability · score 0.56
- Autosomal dominant primary hypomagnesemia with hypocalciuria · score 0.55
- systolic blood pressure · score 0.45
- reticulocyte count · score 0.42
- hereditary spastic paraplegia 45 · score 0.41
- Autosomal recessive spastic paraplegia type 48 · score 0.41
- leukocyte count · score 0.39
- protein measurement · score 0.38
- mean corpuscular volume · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8M5-F1 | alphafold | PREDICTED | 70.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8M5.
Amino-acid sequence (875 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNNM2?
The strongest Open Targets associations for CNNM2 are familial primary hypomagnesemia with normocalciuria and normocalcemia, hypomagnesemia, seizures, and intellectual disability, Autosomal dominant primary hypomagnesemia with hypocalciuria, systolic blood pressure and reticulocyte count.
How long is the CNNM2 protein?
The Homo sapiens CNNM2 protein (UniProt Q9H8M5) is 875 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8M5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8M5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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