Polyprenal reductase (SRD5A3)
Homo sapiens — UniProt Q9H8P0
Data last refreshed: (UniProt release unknown)
Key facts
Polyprenal reductase (SRD5A3) is a protein from Homo sapiens identified by UniProt accession Q9H8P0, 318 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q9H8P0; gene symbol SRD5A3.
- Organism: Homo sapiens.
- Length: 318 amino acids.
- Top disease associations (Open Targets): SRD5A3-congenital disorder of glycosylation, Kahrizi syndrome and benign prostatic hyperplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polyprenal reductase |
|---|---|
| UniProt accession | Q9H8P0 |
| Gene | SRD5A3 |
| Organism | Homo sapiens |
| Length | 318 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- SRD5A3-congenital disorder of glycosylation · score 0.81
- Kahrizi syndrome · score 0.73
- benign prostatic hyperplasia · score 0.60
- prostate carcinoma · score 0.57
- prostate cancer · score 0.56
- congenital disorder of glycosylation · score 0.55
- neurodegenerative disease · score 0.50
- alcohol dependence · score 0.46
- alcohol abuse · score 0.46
- Abnormality of the nervous system · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8P0-F1 | alphafold | PREDICTED | 88.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8P0.
Amino-acid sequence (318 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SRD5A3?
The strongest Open Targets associations for SRD5A3 are SRD5A3-congenital disorder of glycosylation, Kahrizi syndrome, benign prostatic hyperplasia, prostate carcinoma and prostate cancer.
How long is the SRD5A3 protein?
The Homo sapiens SRD5A3 protein (UniProt Q9H8P0) is 318 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8P0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8P0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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