Pleckstrin homology domain-containing family F member 2 (PLEKHF2)
Homo sapiens — UniProt Q9H8W4
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) is a protein from Homo sapiens identified by UniProt accession Q9H8W4, 249 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9H8W4; gene symbol PLEKHF2.
- Organism: Homo sapiens.
- Length: 249 amino acids.
- Top disease associations (Open Targets): platelet component distribution width, mean corpuscular hemoglobin concentration and serum alanine aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family F member 2 |
|---|---|
| UniProt accession | Q9H8W4 |
| Gene | PLEKHF2 |
| Organism | Homo sapiens |
| Length | 249 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.36
- mean corpuscular hemoglobin concentration · score 0.12
- serum alanine aminotransferase measurement · score 0.12
- PHF-tau measurement · score 0.11
- heel bone mineral density · score 0.10
- erythrocyte count · score 0.08
- serum gamma-glutamyl transferase measurement · score 0.08
- diastolic blood pressure · score 0.05
- red blood cell density measurement · score 0.05
- body height · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8W4-F1 | alphafold | PREDICTED | 86.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8W4.
Amino-acid sequence (249 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHF2?
The strongest Open Targets associations for PLEKHF2 are platelet component distribution width, mean corpuscular hemoglobin concentration, serum alanine aminotransferase measurement, PHF-tau measurement and heel bone mineral density.
How long is the PLEKHF2 protein?
The Homo sapiens PLEKHF2 protein (UniProt Q9H8W4) is 249 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8W4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8W4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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