E3 ubiquitin-protein ligase TRIM45 (TRIM45)
Homo sapiens — UniProt Q9H8W5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRIM45 (TRIM45) is a protein from Homo sapiens identified by UniProt accession Q9H8W5, 580 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9H8W5; gene symbol TRIM45.
- Organism: Homo sapiens.
- Length: 580 amino acids.
- Top disease associations (Open Targets): acute myeloid leukemia, hepatocellular carcinoma and Sepsis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM45 |
|---|---|
| UniProt accession | Q9H8W5 |
| Gene | TRIM45 |
| Organism | Homo sapiens |
| Length | 580 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.20
- hepatocellular carcinoma · score 0.06
- Sepsis · score 0.05
- neoplasm · score 0.04
- glioblastoma multiforme · score 0.04
- worry measurement · score 0.03
- breast cancer · score 0.02
- Cerebral ischemia · score 0.02
- blood protein measurement · score 0.02
- non-small cell lung carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8W5-F1 | alphafold | PREDICTED | 79.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8W5.
Amino-acid sequence (580 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM45?
The strongest Open Targets associations for TRIM45 are acute myeloid leukemia, hepatocellular carcinoma, Sepsis, neoplasm and glioblastoma multiforme.
How long is the TRIM45 protein?
The Homo sapiens TRIM45 protein (UniProt Q9H8W5) is 580 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8W5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8W5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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