tRNA endonuclease ANKZF1 (ANKZF1)
Homo sapiens — UniProt Q9H8Y5
Data last refreshed: (UniProt release unknown)
Key facts
tRNA endonuclease ANKZF1 (ANKZF1) is a protein from Homo sapiens identified by UniProt accession Q9H8Y5, 726 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9H8Y5; gene symbol ANKZF1.
- Organism: Homo sapiens.
- Length: 726 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA endonuclease ANKZF1 |
|---|---|
| UniProt accession | Q9H8Y5 |
| Gene | ANKZF1 |
| Organism | Homo sapiens |
| Length | 726 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- lysosomal storage disease · score 0.43
- Alzheimer disease · score 0.23
- Parkinson disease · score 0.23
- multiple sclerosis · score 0.23
- inflammatory bowel disease · score 0.19
- triglyceride measurement · score 0.09
- platelet component distribution width · score 0.08
- mean platelet volume · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H8Y5-F1 | alphafold | PREDICTED | 68.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H8Y5.
Amino-acid sequence (726 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKZF1?
The strongest Open Targets associations for ANKZF1 are neurodegenerative disease, lysosomal storage disease, Alzheimer disease, Parkinson disease and multiple sclerosis.
How long is the ANKZF1 protein?
The Homo sapiens ANKZF1 protein (UniProt Q9H8Y5) is 726 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H8Y5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H8Y5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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