Receptor expression-enhancing protein 1 (REEP1)
Homo sapiens — UniProt Q9H902
Data last refreshed: (UniProt release unknown)
Key facts
Receptor expression-enhancing protein 1 (REEP1) is a protein from Homo sapiens identified by UniProt accession Q9H902, 201 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9H902; gene symbol REEP1.
- Organism: Homo sapiens.
- Length: 201 amino acids.
- Top disease associations (Open Targets): Autosomal dominant spastic paraplegia type 31, hereditary spastic paraplegia 31 and neuronopathy, distal hereditary motor, type 5B.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Receptor expression-enhancing protein 1 |
|---|---|
| UniProt accession | Q9H902 |
| Gene | REEP1 |
| Organism | Homo sapiens |
| Length | 201 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- Autosomal dominant spastic paraplegia type 31 · score 0.81
- hereditary spastic paraplegia 31 · score 0.75
- neuronopathy, distal hereditary motor, type 5B · score 0.58
- hereditary spastic paraplegia · score 0.54
- cardiomyopathy · score 0.46
- Distal hereditary motor neuropathy type 5 · score 0.46
- neuronopathy, distal hereditary motor, autosomal recessive 4 · score 0.46
- Spastic paraplegia · score 0.43
- genetic disorder · score 0.41
- platelet count · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H902-F1 | alphafold | PREDICTED | 67.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H902.
Amino-acid sequence (201 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with REEP1?
The strongest Open Targets associations for REEP1 are Autosomal dominant spastic paraplegia type 31, hereditary spastic paraplegia 31, neuronopathy, distal hereditary motor, type 5B, hereditary spastic paraplegia and cardiomyopathy.
How long is the REEP1 protein?
The Homo sapiens REEP1 protein (UniProt Q9H902) is 201 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H902 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H902 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.