Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (MTHFD2L)
Homo sapiens — UniProt Q9H903
Data last refreshed: (UniProt release unknown)
Key facts
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (MTHFD2L) is a protein from Homo sapiens identified by UniProt accession Q9H903, 347 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9H903; gene symbol MTHFD2L.
- Organism: Homo sapiens.
- Length: 347 amino acids.
- Top disease associations (Open Targets): leukocyte count, low density lipoprotein cholesterol measurement and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial |
|---|---|
| UniProt accession | Q9H903 |
| Gene | MTHFD2L |
| Organism | Homo sapiens |
| Length | 347 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.34
- low density lipoprotein cholesterol measurement · score 0.31
- neutrophil count · score 0.26
- granulocyte count · score 0.23
- response to vaccine · score 0.20
- cytokine measurement · score 0.20
- myeloid white cell count · score 0.20
- monocyte count · score 0.20
- mortality · score 0.16
- response to allogeneic hematopoietic stem cell transplant · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H903-F1 | alphafold | PREDICTED | 89.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H903.
Amino-acid sequence (347 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTHFD2L?
The strongest Open Targets associations for MTHFD2L are leukocyte count, low density lipoprotein cholesterol measurement, neutrophil count, granulocyte count and response to vaccine.
How long is the MTHFD2L protein?
The Homo sapiens MTHFD2L protein (UniProt Q9H903) is 347 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H903 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H903 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.