Mitochondrial glutamate carrier 1 (SLC25A22)
Homo sapiens — UniProt Q9H936
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial glutamate carrier 1 (SLC25A22) is a protein from Homo sapiens identified by UniProt accession Q9H936, 323 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q9H936; gene symbol SLC25A22.
- Organism: Homo sapiens.
- Length: 323 amino acids.
- Top disease associations (Open Targets): myoclonic epilepsy, developmental and epileptic encephalopathy and early myoclonic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial glutamate carrier 1 |
|---|---|
| UniProt accession | Q9H936 |
| Gene | SLC25A22 |
| Organism | Homo sapiens |
| Length | 323 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- myoclonic epilepsy · score 0.69
- developmental and epileptic encephalopathy · score 0.68
- early myoclonic encephalopathy · score 0.63
- malignant migrating partial seizures of infancy · score 0.37
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.13
- Macrocephaly · score 0.12
- developmental disability · score 0.12
- intraocular pressure measurement · score 0.12
- Seizure · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H936-F1 | alphafold | PREDICTED | 78.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H936.
Amino-acid sequence (323 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC25A22?
The strongest Open Targets associations for SLC25A22 are myoclonic epilepsy, developmental and epileptic encephalopathy, early myoclonic encephalopathy, malignant migrating partial seizures of infancy and genetic disorder.
How long is the SLC25A22 protein?
The Homo sapiens SLC25A22 protein (UniProt Q9H936) is 323 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H936 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H936 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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