Mediator of RNA polymerase II transcription subunit 20 (MED20)
Homo sapiens — UniProt Q9H944
Data last refreshed: (UniProt release unknown)
Key facts
Mediator of RNA polymerase II transcription subunit 20 (MED20) is a protein from Homo sapiens identified by UniProt accession Q9H944, 212 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9H944; gene symbol MED20.
- Organism: Homo sapiens.
- Length: 212 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 20 |
|---|---|
| UniProt accession | Q9H944 |
| Gene | MED20 |
| Organism | Homo sapiens |
| Length | 212 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- mean corpuscular volume · score 0.28
- mean corpuscular hemoglobin · score 0.24
- pancreatic adenocarcinoma · score 0.22
- Red cell distribution width · score 0.13
- breast adenocarcinoma · score 0.11
- age at menarche · score 0.10
- angina pectoris · score 0.09
- monocyte percentage of leukocytes · score 0.09
- mean reticulocyte volume · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H944-F1 | alphafold | PREDICTED | 91.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H944.
Amino-acid sequence (212 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MED20?
The strongest Open Targets associations for MED20 are neurodegenerative disease, mean corpuscular volume, mean corpuscular hemoglobin, pancreatic adenocarcinoma and Red cell distribution width.
How long is the MED20 protein?
The Homo sapiens MED20 protein (UniProt Q9H944) is 212 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H944 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H944 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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