WD repeat-containing protein 54 (WDR54)
Homo sapiens — UniProt Q9H977
Data last refreshed: (UniProt release unknown)
Key facts
WD repeat-containing protein 54 (WDR54) is a protein from Homo sapiens identified by UniProt accession Q9H977, 334 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9H977; gene symbol WDR54.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): Stress urinary incontinence, acute lymphoblastic leukemia and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WD repeat-containing protein 54 |
|---|---|
| UniProt accession | Q9H977 |
| Gene | WDR54 |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- Stress urinary incontinence · score 0.08
- acute lymphoblastic leukemia · score 0.07
- appendicular lean mass · score 0.04
- neoplasm · score 0.02
- esophageal squamous cell carcinoma · score 0.02
- head and neck squamous cell carcinoma · score 0.01
- clear cell renal carcinoma · score 0.01
- breast cancer · score 0.01
- cancer · score 0.01
- systemic juvenile idiopathic arthritis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H977-F1 | alphafold | PREDICTED | 92.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H977.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDR54?
The strongest Open Targets associations for WDR54 are Stress urinary incontinence, acute lymphoblastic leukemia, appendicular lean mass, neoplasm and esophageal squamous cell carcinoma.
How long is the WDR54 protein?
The Homo sapiens WDR54 protein (UniProt Q9H977) is 334 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H977 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H977 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.