Actin-related protein 8 (ACTR8)
Homo sapiens — UniProt Q9H981
Data last refreshed: (UniProt release unknown)
Key facts
Actin-related protein 8 (ACTR8) is a protein from Homo sapiens identified by UniProt accession Q9H981, 624 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9H981; gene symbol ACTR8.
- Organism: Homo sapiens.
- Length: 624 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Actin-related protein 8 |
|---|---|
| UniProt accession | Q9H981 |
| Gene | ACTR8 |
| Organism | Homo sapiens |
| Length | 624 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- breast adenocarcinoma · score 0.23
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- clear cell renal carcinoma · score 0.10
- drug use measurement · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- hemoglobin D disease · score 0.05
- primary familial polycythemia due to EPO receptor mutation · score 0.05
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H981-F1 | alphafold | PREDICTED | 86.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H981.
Amino-acid sequence (624 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACTR8?
The strongest Open Targets associations for ACTR8 are neurodegenerative disease, breast adenocarcinoma, ovarian cancer, glioblastoma multiforme and clear cell renal carcinoma.
How long is the ACTR8 protein?
The Homo sapiens ACTR8 protein (UniProt Q9H981) is 624 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H981 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H981 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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